Monthly Archives: July 2010

PubMed madness

i think some StumbleUpon stoner really amped for California Proposition 19 has gone batshit on PubMed. i’ve stumbledupon three awesome studies in the past week that study the carcinogenic effects of marijuana, the link between marijuana and Alzheimer’s, and the effects of marijuana on cognitive performance, and all three have come out favorably. maybe the negative studies just gets thumbs down, but i really don’t think so. weed rules. mostly, i’m creating this post for my own reference (with the newest studies toward the top) and i’ll try to keep updating it (if i encounter more studies).

A molecular link between the active component of marijuana and Alzheimer’s disease pathology. (2006)
Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Alzheimer’s disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer’s disease are expected to triple over the next 50 years. Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients and reduce the health care costs attributable to Alzheimer’s disease. Here, we demonstrate that the active component of marijuana, Delta9-tetrahydrocannabinol (THC), competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid beta-peptide (Abeta) aggregation, the key pathological marker of Alzheimer’s disease. Computational modeling of the THC-AChE interaction revealed that THC binds in the peripheral anionic site of AChE, the critical region involved in amyloidgenesis. Compared to currently approved drugs prescribed for the treatment of Alzheimer’s disease, THC is a considerably superior inhibitor of Abeta aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.

Cannabis and tobacco smoke are not equally carcinogenic. (2004)
Biology Department, 1420 Austin Bluffs Parkway, University of Colorado, Colorado Springs, 80918, USA
More people are using the cannabis plant as modern basic and clinical science reaffirms and extends its medicinal uses. Concomitantly, concern and opposition to smoked medicine has occurred, in part due to the known carcinogenic consequences of smoking tobacco. Are these reactions justified? While chemically very similar, there are fundamental differences in the pharmacological properties between cannabis and tobacco smoke. Cannabis smoke contains cannabinoids whereas tobacco smoke contains nicotine. Available scientific data, that examines the carcinogenic properties of inhaling smoke and its biological consequences, suggests reasons why tobacco smoke, but not cannabis smoke, may result in lung cancer.

Effects of acute smoked marijuana on complex cognitive performance. (2001)
Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.
Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after acute marijuana use has not been adequately assessed under experimental conditions. In the present study, we used a within-participant double-blind design to evaluate the effects acute marijuana smoking on complex cognitive performance in experienced marijuana smokers. Eighteen healthy research volunteers (8 females, 10 males), averaging 24 marijuana cigarettes per week, completed this three-session outpatient study; sessions were separated by at least 72-hrs. During sessions, participants completed baseline computerized cognitive tasks, smoked a single marijuana cigarette (0%, 1.8%, or 3.9% Delta(9)-THC w/w), and completed additional cognitive tasks. Blood pressure, heart rate, and subjective effects were also assessed throughout sessions. Marijuana cigarettes were administered in a double-blind fashion and the sequence of Delta(9)-THC concentration order was balanced across participants. Although marijuana significantly increased the number of premature responses and the time participants required to complete several tasks, it had no effect on accuracy on measures of cognitive flexibility, mental calculation, and reasoning. Additionally, heart rate and several subjective-effect ratings (e.g., “Good Drug Effect,” “High,” “Mellow”) were significantly increased in a Delta(9)-THC concentration-dependent manner. These data demonstrate that acute marijuana smoking produced minimal effects on complex cognitive task performance in experienced marijuana users.

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Positive Drug Story (after Bill Hicks)

…today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and … Continue reading

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rules for breathing poetry

a line break is not the time to take a breath. a comma is the perfect time for a quick breath. a period is the perfect time for a natural breath. are there exclamation marks!!!!? do you see italics? do … Continue reading

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the Internet, while droning hunk

oh my god. oh my god someone hold me. we are speaking through photons. the deaf might be left unimpressed but holy shit oh my god eyeball photon digital photon eyeball delights my mind more than hand waving. it is … Continue reading

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Jesus Walks – Kanye West (2004)

since last summer, i’ve been kind of obsessed with Kanye. while a lot of people seemed to be put off by his 2008 breakup album 808s & Heartbreak, i found its electro pop goodness irresistible.

well, now i’m finally getting into original Kanye for real. last week and this week, i listened to The College Dropout all the way through and i’m still pretty damn impressed. the one track that always sticks out, though, every single time, is “Jesus Walks,” the album’s third single. a mid-tempo military march, the song never fails to get stuck in my head. am i surprised that a song proclaiming the glory of Jesus Christ would catch my attention? hell no (see: Handel’s Messiah). while some of the flows flop like stupid yawns (why are you quoting Happy Gilmore?), these rhymes just inspire:

…I ain’t here to argue about his facial features,
But here to convert atheists into believers.
I’m just trying to say the way school need teachers,
The way Kathie Lee needed Regis, that’s the way I need Jesus.
So here go my single dog, radio needs this
They say you can rap about anything except for Jesus.
That means guns, sex, lies, videotape
But if I talk about God, my record won’t get played, huh?
Well let this take away from my spins,
Which will probably take away from my ends,
Then I hope this take away from my sins
And bring the day that I’m dreaming about
Next time I’m in the club everybody screaming out…

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Don’t Think Twice, It’s All Right – Bob Dylan (1963) [archive]

It ain’t no use to sit and wonder why, babe It don’t matter, anyhow An’ it ain’t no use to sit and wonder why, babe If you don’t know by now When your rooster crows at the break of dawn … Continue reading

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Beginning to See the Light – The Velvet Underground (1969)

near the end of the first song on the second side of the Velvet Underground’s third album, we get some choice Lou Reed lyrical genius. There are problems in these times But woo! none of them are mine Baby, I’m … Continue reading

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fib on each eye

i look crazy with these eyes black and yellow my mind is half as terrifying.

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make big plans (make no small plans)

a poem about spontaneously flying to Chicago to experience loved electronic rock live, without worrying about where to lay my weary head at night. Continue reading

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LCD Soundsystem – LCD Soundsystem (2005) [archive]

the first track on each of the album’s two discs references Daft Punk. of course this is a great album. this is one of the few albums (up there with the White Album, Drukqs, etc.) that i think truly deserves … Continue reading

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